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Insulin Resistance & Diabetes

Network analysis of adipose tissue gene expression highlights altered metabolic and regulatory transcriptomic activity in high-fat-diet-fed IL-1RI knockout mice

M. J. Morine; S. Toomey; F. C. McGillicuddy; C. M. Reynolds; K. A. Power; J. A. Browne; C. Loscher; K. H. Mills; H. M. Roche Network analysis of adipose tissue gene expression highlights altered metabolic and regulatory transcriptomic activity in high-fat-diet-fed IL-1RI knockout mice J Nutr Biochem
Insulin Resistance & Diabetes

Beneficial actions of the [A14K] analog of the frog skin peptide PGLa-AM1 in mice with obesity and degenerative diabetes: A mechanistic study

V. Musale; R. C. Moffett; J. M. Conlon; P. R. Flatt; Y. H. Abdel-Wahab Beneficial actions of the [A14K] analog of the frog skin peptide PGLa-AM1 in mice with obesity and degenerative diabetes: A mechanistic study
Genetics Insulin Resistance & Diabetes

Glucagon receptor antagonist and GIP agonist combination for diet-induced obese mice

L. M. McShane; N. Irwin; D. O'Flynn; Z. J. Franklin; C. M. Hewage; F. P. O'Harte Glucagon receptor antagonist and GIP agonist combination for diet-induced obese mice J Endocrinol
Insulin Resistance & Diabetes

Medications Activating Tubular Fatty Acid Oxidation Enhance the Protective Effects of Roux-en-Y Gastric Bypass Surgery in a Rat Model of Early Diabetic Kidney Disease

W. P. Martin; Y. H. D. Chuah; M. Abdelaal; A. Pedersen; D. Malmodin; S. Abrahamsson; M. Hutter; C. Godson; E. P. Brennan; L. Fändriks; C. W. le Roux; N. G. Docherty Medications Activating Tubular Fatty Acid Oxidation Enhance the Protective Effects of Roux-en-Y Gastric Bypass Surgery in a Rat Model of Early Diabetic Kidney Disease Front Endocrinol (Lausanne)
Chronic Kidney Disease Insulin Resistance & Diabetes

Long-term exposure to a high-fat diet results in the development of glucose intolerance and insulin resistance in interleukin-1 receptor I-deficient mice

F. C. McGillicuddy; C. M. Reynolds; O. Finucane; E. Coleman; K. A. Harford; C. Grant; D. Sergi; L. M. Williams; K. H. Mills; H. M. Roche Long-term exposure to a high-fat diet results in the development of glucose intolerance and insulin resistance in interleukin-1 receptor I-deficient mice Am J Physiol Endocrinol Metab
Insulin Resistance & Diabetes

Beneficial effects of the novel cholecystokinin agonist (pGlu-Gln)-CCK-8 in mouse models of obesity/diabetes

N. Irwin; P. Frizelle; I. A. Montgomery; R. C. Moffett; F. P. M. O'Harte; P. R. Flatt Beneficial effects of the novel cholecystokinin agonist (pGlu-Gln)-CCK-8 in mouse models of obesity/diabetes Diabetologia
Insulin Resistance & Diabetes

A casein hydrolysate protects mice against high fat diet induced hyperglycemia by attenuating NLRP3 inflammasome-mediated inflammation and improving insulin signaling

N. P. Healy; A. M. Kirwan; M. A. McArdle; K. Holohan; A. B. Nongonierma; D. Keane; S. Kelly; L. Celkova; C. L. Lyons; F. C. McGillicuddy; O. M. Finucane; B. A. Murray; P. M. Kelly; L. Brennan; R. J. FitzGerald; H. M. Roche A casein hydrolysate protects mice against high fat diet induced hyperglycemia by attenuating NLRP3 inflammasome-mediated inflammation and improving insulin signaling Mol Nutr Food Res
Insulin Resistance & Diabetes

Endurance exercise training programs intestinal lipid metabolism in a rat model of obesity and type 2 diabetes

Y. H. Hung; M. A. Linden; A. Gordon; R. S. Rector; K. K. Buhman Endurance exercise training programs intestinal lipid metabolism in a rat model of obesity and type 2 diabetes Physiol Rep
Insulin Resistance & Diabetes

Simulating the Post-gastric Bypass Intestinal Microenvironment Uncovers a Barrier-Stabilizing Role for FXR

M. K. Hankir; T. Langseder; E. E. Bankoglu; Y. Ghoreishi; U. Dischinger; M. Kurlbaum; M. Kroiss; C. Otto; C. W. le Roux; T. Arora; F. Seyfried; N. Schlegel Simulating the Post-gastric Bypass Intestinal Microenvironment Uncovers a Barrier-Stabilizing Role for FXR iScience
Insulin Resistance & Diabetes

Glucagon from the phylogenetically ancient paddlefish provides a template for the design of a long-acting peptide with effective anti-diabetic and anti-obesity activities

G. V. Graham; J. M. Conlon; Y. H. Abdel-Wahab; P. R. Flatt Glucagon from the phylogenetically ancient paddlefish provides a template for the design of a long-acting peptide with effective anti-diabetic and anti-obesity activities Eur J Pharmacol
Insulin Resistance & Diabetes

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