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Publication Category: Animal Studies

Long-term treatment with acylated analogues of apelin-13 amide ameliorates diabetes and improves lipid profile of high-fat fed mice

F. P. M. O'Harte; V. Parthsarathy; C. Hogg; P. R. Flatt Long-term treatment with acylated analogues of apelin-13 amide ameliorates diabetes and improves lipid profile of high-fat fed mice PLoS One
Insulin Resistance & Diabetes

Magainin-AM2 improves glucose homeostasis and beta cell function in high-fat fed mice

O. O. Ojo; D. K. Srinivasan; B. O. Owolabi; J. M. Conlon; P. R. Flatt; Y. H. A. Abdel-Wahab Magainin-AM2 improves glucose homeostasis and beta cell function in high-fat fed mice Biochim Biophys Acta
Insulin Resistance & Diabetes

GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity

D. Menon; A. Innes; A. J. Oakley; J. E. Dahlstrom; L. M. Jensen; A. Brüstle; P. Tummala; M. Rooke; M. G. Casarotto; J. B. Baell; N. Nguyen; Y. Xie; M. Cuellar; J. Strasser; J. L. Dahlin; M. A. Walters; G. Burgio; L. A. J. O'Neill; P. G. Board GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity Sci Rep

Network analysis of adipose tissue gene expression highlights altered metabolic and regulatory transcriptomic activity in high-fat-diet-fed IL-1RI knockout mice

M. J. Morine; S. Toomey; F. C. McGillicuddy; C. M. Reynolds; K. A. Power; J. A. Browne; C. Loscher; K. H. Mills; H. M. Roche Network analysis of adipose tissue gene expression highlights altered metabolic and regulatory transcriptomic activity in high-fat-diet-fed IL-1RI knockout mice J Nutr Biochem
Insulin Resistance & Diabetes

Beneficial actions of the [A14K] analog of the frog skin peptide PGLa-AM1 in mice with obesity and degenerative diabetes: A mechanistic study

V. Musale; R. C. Moffett; J. M. Conlon; P. R. Flatt; Y. H. Abdel-Wahab Beneficial actions of the [A14K] analog of the frog skin peptide PGLa-AM1 in mice with obesity and degenerative diabetes: A mechanistic study
Genetics Insulin Resistance & Diabetes

Glucagon receptor antagonist and GIP agonist combination for diet-induced obese mice

L. M. McShane; N. Irwin; D. O'Flynn; Z. J. Franklin; C. M. Hewage; F. P. O'Harte Glucagon receptor antagonist and GIP agonist combination for diet-induced obese mice J Endocrinol
Insulin Resistance & Diabetes

Medications Activating Tubular Fatty Acid Oxidation Enhance the Protective Effects of Roux-en-Y Gastric Bypass Surgery in a Rat Model of Early Diabetic Kidney Disease

W. P. Martin; Y. H. D. Chuah; M. Abdelaal; A. Pedersen; D. Malmodin; S. Abrahamsson; M. Hutter; C. Godson; E. P. Brennan; L. Fändriks; C. W. le Roux; N. G. Docherty Medications Activating Tubular Fatty Acid Oxidation Enhance the Protective Effects of Roux-en-Y Gastric Bypass Surgery in a Rat Model of Early Diabetic Kidney Disease Front Endocrinol (Lausanne)
Chronic Kidney Disease Insulin Resistance & Diabetes

Roux-en-Y gastric bypass in rats progressively decreases the proportion of fat calories selected from a palatable cafeteria diet

C. M. Mathes; C. Letourneau; G. D. Blonde; C. W. le Roux; A. C. Spector Roux-en-Y gastric bypass in rats progressively decreases the proportion of fat calories selected from a palatable cafeteria diet Am J Physiol Regul Integr Comp Physiol
Appetite & Satiety

Long-term exposure to a high-fat diet results in the development of glucose intolerance and insulin resistance in interleukin-1 receptor I-deficient mice

F. C. McGillicuddy; C. M. Reynolds; O. Finucane; E. Coleman; K. A. Harford; C. Grant; D. Sergi; L. M. Williams; K. H. Mills; H. M. Roche Long-term exposure to a high-fat diet results in the development of glucose intolerance and insulin resistance in interleukin-1 receptor I-deficient mice Am J Physiol Endocrinol Metab
Insulin Resistance & Diabetes

Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity

H. Y. Kim; H. J. Lee; Y. J. Chang; M. Pichavant; S. A. Shore; K. A. Fitzgerald; Y. Iwakura; E. Israel; K. Bolger; J. Faul; R. H. DeKruyff; D. T. Umetsu Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity Nat Med

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