Physical activity attenuates the effect of the FTO genotype on obesity traits in European adults: The Food4Me study
- Categories: Basic Science, Physical Activity/Exercise, Weight Loss/Management
- Tags Genetics
Type Article
Journal Article
Authors
C. Celis-Morales; C. F. Marsaux; K. M. Livingstone; S. Navas-Carretero; R. San-Cristobal; B. O'Donovan C; H. Forster; C. Woolhead; R. Fallaize; A. L. Macready; S. Kolossa; J. Hallmann; L. Tsirigoti; C. P. Lambrinou; G. Moschonis; M. Godlewska; A. Surwiłło
Year of publication
2016
Publication/Journal
Obesity (Silver Spring)
Volume
24
Issue
4
Pages
962-9
Abstract
OBJECTIVE: To examine whether the effect of FTO loci on obesity-related traits could be modified by physical activity (PA) levels in European adults. METHODS: Of 1,607 Food4Me participants randomized, 1,280 were genotyped for FTO (rs9939609) and had available PA data. PA was measured objectively using accelerometers (TracmorD, Philips), whereas anthropometric measures [BMI and waist circumference (WC)] were self-reported via the Internet. RESULTS: FTO genotype was associated with a higher body weight [β: 1.09 kg per risk allele, (95% CI: 0.14-2.04), P = 0.024], BMI [β: 0.54 kg m(-2) , (0.23-0.83), P