MicroRNAs in obesity, sarcopenia, and commonalities for sarcopenic obesity: a systematic review

Type Article

Journal Article

Authors

L. Dowling; A. Duseja; T. Vilaca; J. S. Walsh; K. Goljanek-Whysall

Year of publication

2022

Publication/Journal

J Cachexia Sarcopenia Muscle

Volume

13

Issue

1

Pages

68-85

Abstract

Sarcopenic obesity is a distinct condition of sarcopenia in the context of obesity, with the cumulative health risks of both phenotypes. Differential expression of microRNAs (miRNAs) has been reported separately in people with obesity and sarcopenia and may play a role in the pathogenesis of sarcopenic obesity. However, this has not been explored to date. This study aimed to identify differentially expressed miRNAs reported in serum, plasma, and skeletal muscle of people with obesity and sarcopenia and whether there are any commonalities between these conditions. We performed a systematic review on Embase and MEDLINE (PROSPERO, CRD42020224486) for differentially expressed miRNAs (fold change >1.5 or P-value