Liraglutide improves hippocampal synaptic plasticity associated with increased expression of Mash1 in ob/ob mice

Type Article

Journal Article

Authors

W. D. Porter; P. R. Flatt; C. Hölscher; V. A. Gault

Year of publication

2013

Publication/Journal

International Journal of Obesity

Volume

37

Issue

5

Pages

678-684

Abstract

Objective:Consumption of high-fat diet exerts adverse effects on learning and memory formation, which is linked to impaired hippocampal function. Activation of glucagon-like peptide-1 (GLP-1) signalling ameliorates detrimental effects of obesity-diabetes on cognitive function; however, mechanisms underlying these beneficial actions remain unclear. This study examined effects of daily subcutaneous treatment with GLP-1 mimetic, Liraglutide, on synaptic plasticity, hippocampal gene expression and metabolic control in adult obese diabetic (ob/ob) mice.Results:Long-term potentiation (LTP) induced by area CA1 was completely abolished in ob/ob mice compared with lean controls. Deleterious effects on LTP were rescued (P