Insulin receptor substrate-2 gene variants in subjects with metabolic syndrome: Association with plasma monounsaturated and n-3 polyunsaturated fatty acid levels and insulin resistance

Categories: Basic Science, Metabolic Health

Tags Genetics, Insulin Resistance & Diabetes, Metabolic Syndrome

Type Article

Journal Article

Authors

P. Perez-Martinez; J. Delgado-Lista; A. Garcia-Rios; A. C. Tierney; H. L. Gulseth; C. M. Williams; B. Karlström; B. Kieć-Wilk; E. E. Blaak; O. Helal; W. H. M. Saris; C. Defoort; C. A. Drevon; J. A. Lovegrove; A. Dembinska-Kieć; U. Riserus; H. M. Roche; J.

Year of publication

2012

Publication/Journal

Molecular Nutrition and Food Research

Volume

Issue

Pages

309-315

Abstract

Scope: Several insulin receptor substrate-2 (IRS-2) polymorphisms have been studied in relation to insulin resistance and type 2 diabetes. To examine whether the genetic variability at the IRS-2 gene locus was associated with the degree of insulin resistance and plasma fatty acid levels in metabolic syndrome (MetS) subjects. Methods and results: Insulin sensitivity, insulin secretion, glucose effectiveness, plasma fatty acid composition and three IRS-2 tag-single nucleotide polymorphisms (SNPs) were determined in 452 MetS subjects. Among subjects with the lowest level of monounsaturated (MUFA) (below the median), the rs2289046 A/A genotype was associated with lower glucose effectiveness (p