Changes in Glucose Metabolism in Vertical Sleeve Gastrectomy

Categories: Animal Studies, Bariatric Surgery, Basic Science

Tags Insulin Resistance & Diabetes

Type Article

Journal Article

Authors

Y. Lho; C. W. le Roux; H. S. Park; G. S. Kim; J. Jung; G. S. Hwang; Y. K. Seo; T. K. Ha; E. Ha

Year of publication

2015

Publication/Journal

Obes Surg

Volume

Issue

Pages

2002-10

Abstract

BACKGROUND: We evaluated metabolic changes after vertical sleeve gastrectomy (VSG) surgery in a rat model using proteomics and metabolomic profiling in liver and serum. METHODS: Rats were randomly divided into two groups: sham (n = 10) and VSG (n = 12). Food intake, body weight, blood glucose, insulin, and thyroid hormone levels were measured. Two-dimensional electrophoresis, nuclear resonance spectroscopy, mass spectroscopy, immunofluorescence, and immunoblot analyses were used to determine and validate changes in metabolites and proteins in liver tissue and serum samples. RESULTS: Food intake and body weight decreased after VSG group (p