A period 2 genetic variant interacts with plasma SFA to modify plasma lipid concentrations in adults with metabolic syndrome

Categories: Basic Science, Metabolic Health

Tags Genetics, Metabolic Syndrome

Type Article

Journal Article

Authors

A. Garcia-Rios; P. Perez-Martinez; J. Delgado-Lista; C. M. Phillips; I. M. F. Gjelstad; J. W. Wright; B. Karlström; B. Kiéc-Wilk; A. M. J. van Hees; O. Helal; A. Polus; C. Defoort; U. Riserus; E. E. Blaak; J. A. Lovegrove; C. A. Drevon; H. M. Roche; J. Lo

Year of publication

2012

Publication/Journal

Journal of Nutrition

Volume

142

Issue

Pages

1213-1218

Abstract

Genetic variants of Period 2 (PER2), a circadian clock gene, have been linked to metabolic syndrome (MetS). However, it is still unknown whether these genetic variants interact with the various types of plasma fatty acids. This study investigated whether common single nucleotide polymorphisms (SNPs) in the PER2 locus (rs934945 and rs2304672) interact with various classes of plasma fatty acids to modulate plasma lipid metabolism in 381 participants with MetS in the European LIPGENE study. Interestingly, the rs2304672 SNP interactedwith plasma total SFA concentrations to affect fasting plasma TG, TG-rich lipoprotein (TRL-TG), total cholesterol, apoC-II, apoB, and apoB-48 concentrations (P-interactionmedian) had a higher plasma TG concentration (P = 0.001) and higher TRL-TG (Pmedian) had higher plasma concentrations of apo C-II (P