The importance of maternal insulin resistance throughout pregnancy on neonatal adiposity
R. A. Lima; G. Desoye; D. Simmons; R. Devlieger; S. Galjaard; R. Corcoy; J. M. Adelantado; F. Dunne; J. Harreiter; A. Kautzky-Willer; P. Damm; E. R. Mathiesen; D. M. Jensen; L. T. Andersen; M. Tanvig; A. Lapolla; M. G. Dalfra; A. Bertolotto; U. Manta; E.
Year of publication
Paediatr Perinat Epidemiol
BACKGROUND: Although previous studies evaluated the association of maternal health parameters with neonatal adiposity, little is known regarding the complexity of the relationships among different maternal health parameters throughout pregnancy and its impact on neonatal adiposity. OBJECTIVES: To evaluate the direct and indirect associations between maternal insulin resistance during pregnancy, in women with obesity, and neonatal adiposity. In addition, associations between maternal fasting glucose, triglycerides (TG), non-esterified fatty acids (NEFA), and neonatal adiposity were also assessed. METHODS: This is a longitudinal, secondary analysis of the DALI study, an international project conducted in nine European countries with pregnant women with obesity. Maternal insulin resistance (HOMA-IR), fasting glucose, TG, and NEFA were measured three times during pregnancy (