The importance of maternal insulin resistance throughout pregnancy on neonatal adiposity

Categories: Infancy, Maternal, Metabolic Health

Tags Insulin Resistance & Diabetes

Type Article

Journal Article

Authors

R. A. Lima; G. Desoye; D. Simmons; R. Devlieger; S. Galjaard; R. Corcoy; J. M. Adelantado; F. Dunne; J. Harreiter; A. Kautzky-Willer; P. Damm; E. R. Mathiesen; D. M. Jensen; L. T. Andersen; M. Tanvig; A. Lapolla; M. G. Dalfra; A. Bertolotto; U. Manta; E.

Year of publication

2021

Publication/Journal

Paediatr Perinat Epidemiol

Volume

Issue

Pages

83-91

Abstract

BACKGROUND: Although previous studies evaluated the association of maternal health parameters with neonatal adiposity, little is known regarding the complexity of the relationships among different maternal health parameters throughout pregnancy and its impact on neonatal adiposity. OBJECTIVES: To evaluate the direct and indirect associations between maternal insulin resistance during pregnancy, in women with obesity, and neonatal adiposity. In addition, associations between maternal fasting glucose, triglycerides (TG), non-esterified fatty acids (NEFA), and neonatal adiposity were also assessed. METHODS: This is a longitudinal, secondary analysis of the DALI study, an international project conducted in nine European countries with pregnant women with obesity. Maternal insulin resistance (HOMA-IR), fasting glucose, TG, and NEFA were measured three times during pregnancy (