Sexual dimorphism and the placenta – results from the ROLO kids study

Type Article

Journal Article


J. M. T. Donnelly; M. Horan; R. Segurado; E. E. Mooney; S. French; E. J. Molloy; F. M. McAuliffe

Year of publication



J Matern Fetal Neonatal Med






BACKGROUND/AIMS: To assess the association between placental morphology and neonatal and infant anthropometry, including analysis by sex. STUDY DESIGN: Data from the ROLO Kids [Randomized COntrol Trial of LOw Glycaemic Index in Pregnancy] study were analyzed including placental weight and morphology. Placental, anthropometric and skinfold measurements were recorded as markers of adiposity in 196 neonates and 215 infants at 6 months of age. Ratios including subscapular-to-triceps skinfold ratio and waist-to-height ratio were used as markers of central adiposity, while the sum of all skinfolds and subscapular plus triceps skinfolds were used as markers of general adiposity. Analysis was performed for total groups and by sex. RESULTS: On simple linear regression placental weight was associated with neonatal and infant anthropometric measurements. On multiple regression, the placental weight was associated with birth weight. In the neonatal period placental weight was associated with general adiposity in males only (sum of skinfolds (B 0.007, p