Higher circulating bile acid concentrations in obese patients with type 2 diabetes
- Categories: Metabolic Health
Type Article
Journal Article
Authors
R. P. Vincent; S. Omar; S. Ghozlan; D. R. Taylor; G. Cross; R. A. Sherwood; L. Fandriks; T. Olbers; M. Werling; J. Alaghband-Zadeh; C. W. le Roux
Year of publication
2013
Publication/Journal
Annals of Clinical Biochemistry
Volume
50
Issue
4
Pages
360-364
Abstract
Background: Bile acids (BAs) play an important role in releasing incretin hormones via the enteroendocrine L-cell surface TGR5 receptors. The aim of this study was to investigate the difference in BA concentration at baseline and in response to a meal stimulus between type 2 diabetes mellitus (T2DM) and a matched normoglycaemic group. Materials and methods: A cross-sectional study of 12 patients with known T2DM and 12 matched normoglycaemic controls compared BA fractions after an overnight fast and following a standard meal. Results: The T2DM group had higher baseline glucose (P