Examining the connectivity between different cellular processes in the Barrett tissue microenvironment
- Categories: Basic Science, Cancer, Obesity-related conditions
Type Article
Journal Article
Authors
J. J. Phelan; R. Feighery; O. S. Eldin; S. Meachair; A. Cannon; R. Byrne; F. MacCarthy; D. O'Toole; J. V. Reynolds; J. O'Sullivan
Year of publication
2016
Publication/Journal
Cancer Lett
Volume
371
Issue
2
Pages
334-46
Abstract
In Barrett associated tumorigenesis, oxidative phosphorylation and glycolysis are reprogrammed early in the disease sequence and act mutually to promote disease progression. However, the link between energy metabolism and its connection with other central cellular processes within the Barrett microenvironment is unknown. The aim of this study was to examine the relationship between metabolism (ATP5B/GAPDH), hypoxia (HIF1α), inflammation (IL1β/SERPINA3), p53 and obesity status using in-vivo and ex-vivo models of Barrett oesophagus. At the protein level, ATP5B (r = 0.71, P