Rodríguez A, Martín-Loeches I, Moreno G, Díaz E, Ferré C, Salgado M, Marín-Corral J, Estella A, Solé-Violán J, Trefler S, Zaragoza R, Socias L, Borges-Sa M, Restrepo MI, Guardiola JJ, Reyes LF, Albaya-Moreno A, Berlanga AC, Ortiz MDV, Ballesteros JC, Chin
Year of publication
2024
Publication/Journal
Med Intensiva (Engl Ed)
Volume
48
Issue
3
Pages
142-154
Abstract
Objective: To evaluate the impact of obesity on ICU mortality.
Design: Observational, retrospective, multicentre study.
Setting: Intensive Care Unit (ICU).
Patients: Adults patients admitted with COVID-19 and respiratory failure.
Interventions: None.
Primary variables of interest: Collected data included demographic and clinical characteristics, comorbidities, laboratory tests and ICU outcomes. Body mass index (BMI) impact on ICU mortality was studied as (1) a continuous variable, (2) a categorical variable obesity/non-obesity, and (3) as categories defined a priori: underweight, normal, overweight, obesity and Class III obesity. The impact of obesity on mortality was assessed by multiple logistic regression and Smooth Restricted cubic (SRC) splines for Cox hazard regression.
Results: 5,206 patients were included, 20 patients (0.4%) as underweight, 887(17.0%) as normal, 2390(46%) as overweight, 1672(32.1) as obese and 237(4.5%) as class III obesity. The obesity group patients (n = 1909) were younger (61 vs. 65 years, p < 0.001) and with lower severity scores APACHE II (13 [9-17] vs. 13[10-17, p 40 are at high risk of poor outcomes in the ICU. An effective vaccination schedule and prolonged social distancing should be recommended