Age modify the associations of obesity, physical activity, vision and grip strength with functional mobility in Irish aged 50 and older

OBJECTIVE: To estimate whether the associations of obesity, physical activity, vision and grip strength with functional mobility were modified by age. METHODS: Data from The Irish Longitudinal Study on Ageing (2009-2012) were analyzed and 5001 individuals were included in this study. Mobility was assessed by the timed up and go test (TUG-test). Main exposure variables were obesity, physical activity, visual acuity and grip strength at baseline. Multiple linear regression models were fitted to assess the associations of baseline main exposure variables with 2-year follow-up functional mobility and potential confounders were adjusted. Stratified analyses by age were used to assess the interaction between main exposures and age on functional mobility. RESULTS: Multiple linear regression models identified significant interactions of obesity (P