A treat-to-target approach for obesity management: A post hoc analysis of the SURMOUNT-5 trial
- Categories: Medications, Weight Loss/Management
Type Article
Authors
le Roux CW, Busetto L, Aronne L, Horn DB, Dimitriadis GK, Falcon B, Garcia-Perez LE, Valderas EG, Gibble TH, Senyucel C, Dunn JP.
Year of publication
2026
Publication/Journal
Diabetes Obes Metab
Volume
28
Issue
4
Pages
3355-3366
Abstract
Introduction: With new advancements in obesity medicine, clarity on goals and expectations for successful disease management is limited. This post hoc analysis assessed application of proposed treat-to-target (TtT) thresholds for obesity to the outcome measures of SURMOUNT-5, which randomised participants with obesity to tirzepatide or semaglutide. Methods: The proportion of participants in each treatment group reaching proposed TtT thresholds for waist to height ratio (WHtR)